Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

Blueprint Medicines is seeking an exceptional candidate to contribute to preformulation research in a small, fast-paced, and highly collaborative team. This contract position resides within the Formulations Sciences group of Pharmaceutical Sciences. The candidate will work full-time on site and contribute to the execution of laboratory activities related to the transition of novel small molecule compounds from Discovery into Development in support of Blueprint Medicines’ pre-clinical and clinical programs. An ideal candidate will have a strong foundation in analytical techniques such as UPLC/HPLC (Empower proficiency) and an understanding of early drug development processes and experiments. Experience in preformulation development and physicochemical characterization is highly desired, but not required.

An ideal candidate would have approximately 2+ years’ experience working in pharmaceutical sciences (preformulation, analytical or formulation development).

What will you do?

• Prepare buffers and common lab solutions
• Execution of analytical experiments with XRPD, DSC, TGA, DVS, SEM, optical microscopy, and UPLC/HPLC (Empower)
• Screen excipients/formulation vehicles for solubility and stability to optimize preclinical formulations to enable non-GLP and GLP pre-clinical studies
• Perform drug substance and formulation stability studies to ensure optimal formulation design
• Coordinate vehicle/formulation preparations for in vivo studies
• Execute dissolution studies (Distek and Pion µDISS) to support formulation development and FIH development
• Maintain an accurate, timely, and compliant laboratory notebook

What minimum qualifications do we require?

• B.S. degree in chemistry, analytical chemistry, pharmaceutics, chemical engineering, or material sciences
• 2+ years’ experience working in pharmaceutical sciences (preformulation, analytical, or formulation development)
• Experience in the Discovery and Development interface [desirable not required]
• Experience working with common excipients and volumetric glassware
• Proficiency with UPLC/HPLC and Empower Software
• Some knowledge of and interest in learning more about small molecule and pre-clinical formulation development

What additional qualifications will make you a stronger candidate?

• Ability to effectively prioritize and manage multiple tasks and compounds
• Self-motivated and willing to “learn on the job” and ask for assistance when needed
• At home in a results-driven, highly accountable environment where you can make a clear impact
• A team player, who listens effectively and invites responses and discussion
• A collaborator who communicates in an open, clear, complete, timely, and consistent manner

Education

• A Bachelor's degree is required.

Pay Transparency:

The pay range that Magnit reasonably expects to pay for this position: $40.00-$50.00/hour.

Benefits: Medical, Dental, Vision, 401K (provided minimum eligibility hours are met).

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. 

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement.