Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

Job Title: Senior Scientist, Translational Medicine

Location: Cambridge, MA, Hybrid

Job Description:

• Define and execute translational and biomarker plans for Blueprint’s preclinical and clinical-stage allergy and immunology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
• Ensure that discovery, pre-clinical and clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
• Perform and/or oversee experimental design, lab-based research, data analysis, data integration and data storage. Independently conduct, optimize, and proactively troubleshoot assays both in-house and with CRO.
• Manage external biomarker analysis at specialty CROs including experimental design, validation, qualification, budgeting, timelines, and oversight of quality and execution during trial conduct.
• Represent Translational Medicine within project/program teams; share scientific and strategic perspectives, generate data to support team needs, meet project/program milestones for TM responsibilities.
• Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
• Analyze, interpret, and present integrated scientific results and implications for program strategy to internal and external stakeholders.
• Effectively collaborate across internal functions including discovery, translational, clinical pharmacology, clinical development, data management to ensure successful execution in the clinic.
• Clearly communicate translational strategies, timelines, dependencies, risks, and mitigations to team members.
• Evaluate new technologies and partner with external collaborators to enable exploratory biomarkers
• Regularly present research to Translational Medicine and integrated project teams highlighting implications and opportunities for broader program.
• Hands-on experience with molecular and cellular assays development, validation and data analysis is preferred, such as PCR, NGS, Western blotting.
• Extensive experience with state-of-the-art assays, and standard software analytical tools, xlsx, Prism, etc.
• Demonstrated knowledge of clinically relevant biomarker approaches across a range of technology platforms
• Experience working with central laboratories and contract research organizations supporting specialized biomarker analysis
• Familiarity with working in the GxP environment with a focus on quality
• Strong interpersonal and communication skills, with a passion for participating in a fast-paced environment characterized by challenging and rigorous science, and innovative thinking
• Strong oral and written communication skills, as well as excellent documentation and organizational skills are essential
• Familiarity with Companion Diagnostics and personalized medicine development is strongly preferred.
• Familiarity with PK/PD/efficacy relationships and delivering PD readouts for in vivo tumor models is preferred
• A great teammate, who listens effectively and invites response and discussion
• A collaborator who communicates in an open, clear, complete, timely and consistent manner
• PhD in Allergy and Immunology, or related discipline
• Relevant post-doctoral training and/or 4-6 years of relevant experience in a biopharmaceutical research setting
• Research experience in Allergies, Asthma, Anaphylaxis or related disease

Pay Transparency:

The pay range that Magnit reasonably expects to pay for this position: $135.00 - 145.00 /hour.

Benefits: Medical, Dental, Vision, 401K (provided minimum eligibility hours are met).

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity, and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. 

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement. 

Job Location: Cambridge, Massachusetts 

Contract Duration: 6 months

• Work Authorization : Authorized to work in the United States
• Preferred years of experience : 5+ yrs
• Travel Required : No travel required
• Shift timings: Not specified